Thermodynamic Phase Equilibrium Properties of Partially Mis-cible Binary Solvent Mixtures in the Vicinity of the Immis- cibility Critical Point (Expedited Award for Novel Research)

该项目的目的是寻找一类新的溶剂， 类似的热力学性质的流体在其气-液 临界点 目前努力的目标是确认 理论预测二元混合物具有增强的选择性 溶解各种化合物。 超临界萃取过程 受到广泛的关注;然而， 在低温和低压下的临界点是有限的。 它 预期使用薄层色谱板（TLC）作为 固定相和使用各种不混溶的溶剂混合物， CST点作为移动的相。 流动率的差异 各种化合物，近和远的CST点，将 用来测量溶解度。 它特别旨在检查是否 光学活性化合物的二元混合物具有增强的选择性 外消旋混合物组分的CST附近。

The purpose of this project is to find a new class of solvents with similar thermodynamic properties to those of fluids at their gas-liquid critical point. The goal of the present effort is to confirm the theoretical predictions that binary mixtures have enhanced selectivity for dissolving various compounds. Supercritical extraction processes are receiving wide interest; however, the number of liquids which have critical points at both low temperatures and pressures is limited. It is intended to use Thin Layer Chromatographic plates (TLC) as the stationary phase and to use various immiscible solvent mixtures showing a CST point as a mobile phase. The difference in the rates of mobility of various compounds, near and far away from the CST point, will be used as a measure of solubility. It is especially intended to check if binary mixtures of optically active compounds have enhanced selectivity near the CST for the components of a racemic mixture.