EXAFS Investigation of Metalloproteins

所有需氧生物都需要氧气，并需要呼吸蛋白来进行氧气的结合、储存和运输。呼吸蛋白可能是血红蛋白、血红蛋白或血青素，它们都有不同的氧结合位点。对其活性的分子基础的定义与许多关键的生物过程高度相关。Stern博士的主要目标是使用x射线吸收精细结构光谱（EXAFS）继续分析非血红素铁在各种金属蛋白中的作用。研究的主要重点将是发展这些含金属离子系统的生物功能和反应性的物理和化学基础。这项工作既创新又合理，有可能产生重大的新成果。

All aerobic organisms use oxygen and require respiratory proteins to carry out its binding, storage and transport. Respiratory proteins may be hemoglobins, hemerythrins or hemocyanins, each of which have different oxygen binding sites. A definition of the molecular basis of their activity is highly relevant to many key biological processes. Dr. Stern's broad objective is to continue the analysis of the involvement of nonheme iron in various metalloproteins using X-ray absorption fine structure spectroscopy (EXAFS). The major thrust of the research will be to develop the physical and chemical basis of the biological functions and reactivities of these metal ion containing systems. The work is both innovative and sound and has the potential of yielding significant new results.