Development of Cortico Cortical Connectivity in Monkey Association Cortex

本提案中的实验旨在研究 恒河猴大脑前额叶皮层的连通性。 两个脑叶之间联系的最新研究进展 在成熟的猴子的额叶皮层（皮质.皮质连接） 使之成为审查规则和机制的示范制度， 管理他们的发展。 施瓦茨博士将进行实验， 提供两方面发展的详细资料：（1） 皮层神经轴突的生长克里思和方式 前额叶皮层，（2）的产生，目标和克里思 来自胼胝体轴突的突触接触的增殖 以及这些事件与柱状组织的关系。 这些研究将使用 神经解剖示踪剂HRP和氚化氨基酸在 光学和电子显微镜水平。 这些实验的结果将提供重要的新的 关于轴突生长和连接方面的信息 灵长类动物大脑皮层中的一种结构。 的 皮质。灵长类动物前额皮质的皮质连接是 高度发达。 行为模式的相似性 人类额叶受损后发现的损伤， 猴子的前额皮质可能提供了一个 了解结构和功能的重要模型 认知功能的影响。

The experiments in this proposal are designed to examine the development of connectivity in the prefrontal cortex of the rhesus monkey brain. Recent advances in understanding the connections between the two lobes of the frontal cortex (cortico.cortical connec tions) in mature monkeys make this a model system for examining the rules and mechanisms which govern their development. Dr. Schwartz will conduct experiments to provide detailed information on two aspects of development: (1) the tempo and pattern of ingrowth of cortico.cortical axons in the prefrontal cortex, and (2) the generation, targets and tempo of proliferation of synaptic contacts arising from callosal axons and the relationship of these events to columnar organization. These studies will examine fetal and neonatal monkeys using the neuroanatomical tracers HRP and tritiated amino acids at the light and electron microscope level. The results of these experiments will provide important new information on aspects of axonal growth and connectivity formation in the cerebral cortex of developing primates. The cortico.cortical connections in the prefrontal cortex of primates are highly developed. Similarities in the pattern of behavioral impairments found following damage to the frontal lobes in humans and monkeys suggest that the monkey prefrontal cortex may provide an important model for understanding the structure and function of cognitive functions on humans.