Transport Phenomena Associated with Gas-Liquid Dispersions in Tower Fermentors for Plant and Animal Cell Culture Applications

简介：结合哺乳动物和植物细胞的气升式反应器具有很高的商业利用潜力，可以合成各种重要的生物产品(蛋白质等)。空运概念的一些优点包括低剪切率、相对良好的混合以及降低污染风险。气升式反应器最重要的一个方面是，它们为培养提供了一个温和的环境，因此保持了脆弱细胞的完整性，这反过来又减少了不受欢迎的物质释放到肉汤中。这项研究的具体目标是获得关于流体动力的基本知识，并描述多相流中的湍流。这些信息将被用来检查对脆弱培养物的影响，设计固定化培养物的支架，并为空运发酵罐提供放大信息。

Narrative: Airlift reactors incorporating mammalian and plant cells have a high potential for commercial utilization to synthesize a variety of important bioproducts (proteins, etc.). Some advantages of the airlift concept include low shear rates, relatively good mixing, and a decreased risk of contamination. The single most important aspect of air lift reactors is that they provide a gentle environment for the culture and therefore, preserve the integrity of fragile cells, which in turn reduces the release of undesirables into the broth. The specific objective of the research will be to obtain fundamental knowledge about the hydrodynamic forces and to characterize turbulence in multiphase flow. This information will be used to examine effects on fragile cultures, design supports for immobilized cultures, and provide scale-up information for airlift fermentors.