Hormonal Determinants of Brain Development

提出的研究涉及性腺类固醇在啮齿动物大脑皮层分化和发育中的神经生物学作用。主要使用组织培养方法，实验旨在定义皮质雌激素受体的个体发生方面，并表征受体/雌激素相互作用对受体和受体正常发育的重要性。包含 细胞。托兰博士。Allerand将研究：(1)雌激素对特定细胞群（神经元和神经胶质）的影响，以及(2)雌激素对编码细胞骨架蛋白和与神经突生长相关的基因产物的调控。本研究结果将为皮质雌激素受体的神经生物学作用提供重要的新信息。计划中的实验为更好地理解通常调节大脑皮层发育的表观遗传影响提供了一种新的方法，并与先天性神经发育障碍的发生有关。

The proposed studies deal with the neurobiological role of the gonadal steroids in the differentiation and development of the rodent cerebral cortex. Using primarily a tissue culture approach, the experiments are designed to define ontogenetic aspects of the cortical estrogen receptor and to characterize the importance of receptor/estrogen interactions for the normal development of both the receptor and the receptor.containing cells. Dr. Toran.Allerand will examine: (1) the effects of estrogen on defined cell populations (neurons and neuroglia), and (2) estrogen regulation of genes encoding cytoskeletal proteins and the gene products associated with neurite growth. The results of this research will yield important new information on the neurobiological role of cortical estrogen receptors. The planned experiments offer a novel approach to a better understanding of the epigenetic influences which normally modulate cerebral cortical development, with relevance for the genesis of congenital disorders of neural development.