Cyclization Approaches to Natural Products (Chemistry)

本研究项目隶属于有机和大分子化学专业，旨在深入了解有机化合物的分子结构和反应性。这一新知识是通过制备和研究在天然产物中遇到的具有代表性的多功能类型的新分子来获得的。将在天然产物化学领域进行若干项目。新的环化反应将导致进入诺加霉素类抗肿瘤抗生素的关键中间体，cervinomycin（一类新的抗生素聚酮生物碱）和hormothamnione（一种多氧色素，具有令人印象深刻的抗肿瘤活性）将被研究。具体的合成方法包括在碳水化合物化学中使用芳基自由基和在不对称聚酮合成中使用定向醛醇缩合反应。

This research project in the Organic and Macromolecular Chemistry Program is designed to provide deeper understanding of molecular structure and reactivity in organic compounds. This new knowledge is to be gained through preparation and study of new molecules representative of polyfunctional types encountered among natural products. Several projects will be pursued in the areas of natural products chemistry. New cyclization reactions which will lead to key intermediates for entry into the nogalamycin class of anti-tumor antibiotics, the cervinomycins (a new class of antibiotic polyketide alkaloids), and hormothamnione (a polyoxygenated chromone which exhibits impressive antitumor activity) will be investigated. The specific synthetic methods to be developed involve the use of aryl radicals in carbohydrate chemistry and directed aldol condensation reactions in unsymmetrical polyketide synthesis.