Structure and Dynamics of Transfer RNA

从结构的角度来看，tRNA是一类重要的分子。它们是第一个被测序并用于结晶学分析的自然产生的核酸，它们包含许多与核酸结构相同的特征。从生物学上讲，它们处于将遗传密码转换为蛋白质序列的机器的中心，并与大量其他大分子相互作用。更深入地了解决定tRNA结构、动力学和相互作用的原理是一个重要的目标。哈维博士将继续开发基于计算机的转移RNA模型，并使用这些模型来研究有关tRNA结构、动力学以及与其他分子相互作用的一系列问题。

From a structural standpoint, tRNA's are an important class of molecules. They were the first naturally occurring nucleic acids to be sequenced and to yield to crystallographic analysis, and they contain many features common to nucleic acid structure. Biologically, they stand at the center of the machinery for translating the genetic code into protein sequences and they interact with a large number of other macromolecules. A deeper understanding of the principles that determine tRNA structure, dynamics and interactions is an important goal. Dr. Harvey will continue the development of computer-based models for transfer RNA and the use of these models to examine a number of questions about tRNA structure, dynamics and interactions with other molecules.