Fluorescence Imaging Facilities Center

这份生物设施中心提案要求资金建立一个荧光成像设施中心。荧光成像中心将利用生物医学科学荧光研究中心、匹兹堡超级计算机中心、艺术与技术中心和几家公司的优势。该设施中心将整合定量荧光显微镜、成像技术、计算科学、图形显示计算机科学和先进仪器开发技术，构建面向生物医学科学的下一代定量荧光显微镜/成像系统。一个系统将组装用于活细胞和组织的荧光光谱，另一个系统将用于免疫荧光和基于荧光的核酸探针的原位杂交。这些系统将对细胞、发育和分子生物学的研究产生直接影响。所开发的仪器和方法在完全投入使用时将直接使荧光中心的30名研究人员受益。该中心以外的研究人员将受益于新的尖端设备的开发，因为在未来几年内，所有生物医学研究人员都可以使用这些设备。

This Biological Facilities Center proposal requests funds to establish a fluorescence imaging facilities center. The fluorescence imaging center will draw on the strengths of the Center for Fluorescence Research in Biomedical Sciences, the Pittsburgh Supercomputer Center, the Center for Art and Technology, and several companies. This facilities center will integrate the technologies of quantitative fluorescence microscopy, imaging technology, computational science, graphics display computer science, and advanced instrumentation developments to construct the next generation quantitative fluorescence microcope/imaging system for the biomedical sciences. One system will be assembled for fluorescence spectroscopy on living cells and tissues and another for immunofluorescence and fluorescence-based in situ hybridization of nucleic acid probes. These systems will have an immediate impact on research in cellular, developmental, and molecular biology. The instrumentation and methodology developed will directly benefit 30 researchers in the Fluorescence Center when fully operational. Researchers outside of the Center will benefit from the development of new sophisticated equipment as it becomes accessible to all biomedical researchers within the next few years.