Calcium Channels: NYAS Conference; on July 18-20, 1988, London, England.

这次会议由纽约科学院主办，将重点介绍过去几年在可兴奋组织中的钙通道方面取得的显著进展。取得进展的主要原因是新的Ca++通道配体的发展和单个Ca++通道分子详细功能研究的新方法。因此，几种不同的钙离子通道类型具有不同的生物物理、生理、药理和调节特性。建立了离子渗透和通道门控机制的新模型。新的高亲和力配体已经允许化学纯化和阐明至少一种通道类型的亚基组成，通道分布的定位以及观察发育期间和各种疾病中的ca++通道表达。此外，针对Ca++通道的抗体与Lambert-Eaton肌无力综合征的发病机制有关，并且在肌肉发育不良中已证实Ca++通道的特异性缺失。Ca++通道的研究已经发展成为一个真正的多学科的努力。会议将汇集来自神经生物学、生物化学、分子生物学、生理学和药理学的科学家，每个人都为理解这一相关的生物信号通路做出了重要贡献。

This conference sponsored by the New York Academy of Sciences will highlight the remarkable progress achieved over the last few years concerning calcium channels in excitable tissues. Advances were mainly possible because of the development of new Ca++ channel ligands and of new methods for the detailed functional investigation of single Ca++ channel molecules. Thus, several distinct Ca++ channel types with different biophysical, physiological, pharmacological and regulatory properties have been identified. New models for the mechanisms of ion permeation and channel gating have been developed. New high-affinity ligands have allowed the chemical purification and elucidation of the subunit composition of at least one channel type, the localization of channel distribution as well as the observation of Ca++ channel expression during development and in various diseases. Additionally, antibodies against Ca++ channels have been implicated in the pathogenesis of Lambert-Eaton Myasthenic Syndrome, and a specific absence of Ca++ channels has been demonstrated in muscular dysgenesis. Ca++ channel study has evolved into a truly multi-disciplinary effort. The conference will bring together scientists from neurobiology, biochemistry, molecular biology, physiology and pharmacology, each contributing a vital part to the understanding of this relevant biological signalling pathway.