Center for Biophysical Studies on Macromolecular Assemblies

定量系统生物学的研究和培训中心， 将建立有组织的大分子组装体。 中心， 该中心的正式名称是大分子生物物理研究中心， 大会，将是一个新的生物物理研究所的组成部分， 约翰霍普金斯大学正在进行的研究。 的 研究所和生物研究中心将整合教师 来自不同的校园。 现在已知大分子组装体是 广泛传播，包括基因转录复合物，膜 运输系统、收缩纤维和DNA上存在的复合物 复制分叉。 这些集合体是生命的核心元素 过程和谎言之间的传统学科的接口， 细胞生物学和生物化学。 四个相互作用的项目将是 生物研究中心的最初研究重点，即 蛋白质-核酸系统的结构和调节相互作用， 细胞骨架的分子力学， 蛋白质寡聚复合物如质子转运ATP酶， 以及蛋白质稳定性和折叠的问题。 的总体努力 该中心将包括合作研究，跨学科 培训、教育和外联。 通过其研究成果 生物物理研究中心（Center for Biophysical Studies on 高分子组装体应该对基本的全球性影响 和应用生物学。 该中心将整合遗传学的新技术， 工程、计算科学和分子图形学，以及 结构仪器，以开发一个框架， 分析大分子复合物的作用机理。 这些技术为定量分析的新时代奠定了基础。 有组织的大分子系统的生物物理学研究。 总 定量生物学和分子生物物理学的学科一直是 被忽视，但随着新技术的出现， 重要. 这些都是基础生物学的核心问题， 这些研究项目将成为基础科学进步的核心。 90年代的生物科学。 此外，这项工作非常 对生物技术的未来发展和 制药行业，以及其他应用。 加强 已经强大的集团，新的教师职位将被创建，以增加 现任教师17人。 一次特殊的博士后培训 该计划将成为该中心的主要组成部分。 此程序将 为青年科学家提供高水平的跨学科培训， 谁将处于有利地位来推动新兴领域的发展 大分子系统生物学 对合作的期望 项目的中心是，一套一般原则和新的 概念框架可能会出现。 这将允许更严格的 对生命系统的理解，以及对 应用生物科学发展未来生物技术。

A research and training center for quantitative systems biology of organized macromolecular assemblies will be established. The center, formally called the Center for Biophysical Studies on Macromolecular Assemblies, will be an integral part of a new Institute for Biophysical Research being developed at The Johns Hopkins University. The Institute and the Biological Research Center will integrate faculty from different campuses. Macromolecular assemblies are now known to be wide spread and include the gene transcription complexes, the membrane transport systems, contractile fibers, and the complexes present at DNA replication forks. These assemblies are central elements to life processes and lie at the interface between traditional disciplines of cell biology and biochemistry. Four interacting projects will be the initial research focus of the Biological Research Center, namely, the structure and regulatory interactions of protein-nucleic acid systems, the molecular mechanics of the cytoskeleton, the structure and function of protein oligomeric complexes such as proton-translocating ATPases, and the problem of protein stability and folding. The overall efforts of the Center will include collaborative research, interdisciplinary training, education and outreach. Through the results of its research and training programs, the Center for Biophysical Studies on Macromolecular Assemblies should have a worldwide impact on fundamental and applied biology. The Center will integrate the new technologies of genetic engineering, computational science and molecular graphics, and structural instrumentation, to develop a framework for the physical analysis of the functional mechanisms of macromolecular complexes. These technologies have set the stage for a new era in the quantitative biophysical study of organized macromolecular systems. The general discipline of quantitative biology and molecular biophysics has been neglected, but with the advent of the new technologies has become very important. These are very central questions in basic biology, and these research projects will be at the core of advances in basic biological sciences in the 1990s. In addition, this work is very important for the future development of biotechnology and the pharmaceutical industry, among other applications. To strengthen the already strong group, new faculty positions will be created to add to the 17 current faculty members. A special postdoctoral training program will form a major component of the Center. This program will provide a high-level interdisciplinary training for young scientists, who will be in a good position to advance the emerging field of macromolecular systems biology. The expectation for the collaborative projects in the center is that a set of general principles and new conceptual frameworks may emerge. This would allow a more rigorous understanding of living systems and more predictive power in the application of biological science to developing future biotechnologies.