Structure and dynamics of class B1 G protein coupled receptors

我们体内的细胞需要细胞表面蛋白（受体）将细胞外刺激转化为适当的生物反应。G蛋白偶联受体是细胞表面受体中最大的一类。本项目重点关注这些受体的一个子集，这些受体在中枢神经系统和外周神经系统中具有多种重要功能，但是关于这些蛋白质的结构以及它们如何调节细胞信号传导还有许多未解之谜。该项目的主要结果将提供详细的机制见解，了解受体如何结合它们的刺激，以及这如何导致它们的激活来介导对所有生物体都很重要的基本信号。

Cells within our body require cell surface proteins (receptors) to convert extracellular stimuli into an appropriate biological response. G protein-coupled receptors are the largest group of cell surface receptors. This project focuses on a subset of these receptors that have diverse and important functions in the central nervous system and the periphery, however there are many unanswered questions regarding the structure of these proteins, and how they regulate cellular signalling. The primary outcomes of this project will provide detailed mechanistic insights on how receptors bind their stimuli and how this results in in their activation to mediate fundamental signalling that is important for all living organisms.