Photoinduced Palladium Catalysis for Next Generation C-H Bond Activation

该项目旨在发现有机分子中碳氢键转化的新方法，作为化学合成的一般策略。在这个项目中，一个关键的概念进步是过渡金属催化和可见光的统一，作为一个强大的工具来激活这些传统上不活跃的，但在烷烃中丰富的化学键。从精细化学品生产到药物发现等领域的应用，这项研究的总体目标是建立新的碳氢键激活反应，并证明这一策略可以转化为具有社会影响的新药、农用化学品和先进合成材料的发明。

This project aims to discover new methods for the conversion of carbon-hydrogen bonds in organic molecules as a general strategy in chemical synthesis. A key conceptual advance in this project is the unification of transition metal catalysis and visible light as a powerful tool to activate these traditionally unreactive, yet abundant chemical bonds in alkanes. With application in fields that range from fine chemical production to drug discovery, the overarching aim of this research is to establish new carbon-hydrogen bond activation reactions and to demonstrate that this strategy can be translated to the invention of new pharmaceuticals, agrochemicals and advanced synthetic materials that will have societal impact.