Laser Microprobe Organic Microanalysis Feasibility Study

这个小型企业创新研究(SBIR)第一阶段项目是在分析和表面化学的一般领域，以及在质谱子领域。本研究的目的是评估激光电离质谱仪(LIMS)的有机微量分析能力。这项技术，也被称为激光微探针质谱，已被证明为选定的有机固体提供有用的有机微量分析数据。然而，对这一潜在独特的化学分析能力还没有进行系统的评估。这项第一阶段的研究将确定LIMS技术在有机固体分析中的总体用途，并可能导致针对这一重要类型的分析问题开发新的LIMS协议和仪器。一期工程包括四个研究任务：(1)获取几种分析条件下典型有机固体的LIMS数据库，(2)分析这些具有重要结构意义的离子峰的质谱图；(3)在可能的情况下，将这些LIMS数据与更传统的质谱学技术产生的数据进行比较；以及(4)在适当的情况下，应用因子分析技术来识别或区分不同固体分析物产生的质谱图。这一实验策略应该提供必要的信息，从这些信息可以评估LIMS有机微量分析的一般用途。

This Small Business Innovation Research (SBIR) Phase I project is in the general area of analytical and surface chemistry and in the subfield of mass spectrometry. The goal of this research activity is to evaluate the organic microanalysis capability of laser ionization mass spectrometry (LIMS). This technique, which is also referred to as laser microprobe mass spectrometry, has been shown to provide useful organic microanalytical data for selected organic solids. However, a systematic evaluation of this potentially unique chemical analysis capability has not been performed. This Phase I research will determine the overall utility of the LIMS technique in organic solids analysis and could lead to the development of new LIMS protocols and instruments for this important type of analytical problem. This Phase I project consists of four research tasks: (1) Acquiring a LIMS data base of representative organic solids at several analysis conditions; (2) Analyzing these mass spectra for structurally significant ion peaks; (3) Comparing, where possible, these LIMS data with those produced by more conventional mass spectrometric techniques; and (4) Applying, where appropriate, factor analysis techniques to identify or distinguish the mass spectra produced from different solid analytes. This experimental strategy should provide the necessary information from which the general utility of LIMS organic microanalysis can be assessed.