Ultra-High-Speed Gas Chromatograph

这个小企业创新研究（SBIR）第一阶段项目是在分析和表面化学的一般领域以及色谱的子领域。本研究活动的目的是确定开发一种超高速色谱仪的可行性，这种色谱仪可以非常快速地分析复杂的样品。为了实现这一点，将检查内径在1到50微米范围内的开管色谱柱，以确定在最大限度地提高分析速度的同时保持分离效率的最佳直径。将开发用于这些微孔毛细管柱的失活，涂层和评估方法，并将开发与它们兼容的新样品导入系统。最后，将开发和评估用于这些超窄口径毛细管柱的优化、兼容的检测器和相关的快速响应电子设备。第一阶段活动的成功完成应该证明后续仪器的开发是否会导致气相色谱仪能够每秒定量15到20个样品成分。这种仪器的可用性将在许多科学和技术领域产生广泛影响，并可能首次使气相色谱法成为许多需要立即分析数据进行过程和质量控制的应用的首选方法。

This Small Business Innovation Research (SBIR) Phase I project is in the general area of analytical and surface chemistry and in the subfield of chromatography. The goal of this research activity is to determine the feasibility of developing an ultra-high speed chromatograph with which complex samples can be very rapidly analyzed. To accomplish this, open tubular chromatographic columns having inside diameters in the range of one to fifty micrometers will be examined to determine the optimal diameter that will enable preservation of separation efficiency while maximizing the speed of analysis. Deactivation, coating, and evaluation methods will be developed for use with these microbore capillary columns, and new sample introduction systems that are compatible with them will be developed. Finally, optimized, compatible detectors and associated fast-response electronics for use with these ultra-narrow-bore capillary columns will be developed and evaluated. The successful completion of this Phase I activity should demonstrate whether subsequent instrument development would lead to a gas chromatograph which would be capable of quantifying fifteen-to-twenty sample components per second. The availability of such an instrument would impact broadly in numerous scientific and technical areas and could, for the first time, make gas chromatography the method of choice for many applications which require immediate analytical data for process and quality control.