The novel TH17-associated cytokine IL-26 mediates BBB breakdown and neuroinflammation
The novel TH17-associated cytokine IL-26 mediates BBB breakdown and neuroinflammation
批准号:
303837
负责人:
Prat Alexandre
金额:
$52.79万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-03-01 至 2019-03-01
中文摘要
免疫细胞从血液到达炎症部位,在那里它们启动并维持组织损伤。正常情况下,由于内皮血脑屏障(BBB)的存在,免疫系统的细胞不容易进入大脑。豪韦
英文摘要
Immune cells travel from the blood to sites of inflammation where they initiate and maintain tissue damage. Normally, the brain is not easily accessible to cells of the immune system due to the presence of the endothelial blood-brain barrier (BBB). Howeve
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会议论文
Canada Research Chair - Tier 1
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批准号:471059
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项目类别:
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资助金额:$101.99万
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财政年份:2022
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负责人:Prat Alexandre
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依托单位:
Integrin Alpha8 is a novel mediator of T lymphocyte migration across the CNS barriers
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批准号:401356
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项目类别:Operating Grants
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资助金额:$57.12万
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财政年份:2019
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负责人:Prat Alexandre
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依托单位:
A transgenic mouse model of multiple sclerosis offers new ways to identify mechanisms of progression and novel therapies
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批准号:357887
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项目类别:Operating Grants
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资助金额:$51.55万
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财政年份:2016
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负责人:Prat Alexandre
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依托单位:
Integrin alpha8 is a novel mediator of pro-inflammatory T lymphocyte migration across the CNS barriers
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批准号:366593
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项目类别:Operating Grants
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资助金额:$7.29万
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财政年份:2016
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负责人:Prat Alexandre
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依托单位:
Canada Research Chair Tier 1
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批准号:315442
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项目类别:
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资助金额:$101.99万
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财政年份:2014
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负责人:Prat Alexandre
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依托单位:
Mechanisms of Lymphocytes Transmigration Across the Blood Brain Barrier
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批准号:313936
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项目类别:Operating Grants
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资助金额:$8.2万
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财政年份:2014
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负责人:Prat Alexandre
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依托单位:
Novel Adhesion Molecules Regulating CNS Inflammation
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批准号:279102
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项目类别:Operating Grants
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资助金额:$53.63万
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财政年份:2013
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负责人:Prat Alexandre
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依托单位:
Cytokines in Health and Diseases
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批准号:187029
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项目类别:Miscellaneous Programs
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资助金额:$0.51万
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财政年份:2009
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负责人:Prat Alexandre
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依托单位:
Role of astrocytes in blood-brain barrier regulation and CNS immunity
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批准号:179067
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项目类别:Operating Grants
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资助金额:$51.82万
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财政年份:2009
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负责人:Prat Alexandre
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依托单位:
国内基金
海外基金
基于“肝主泪”和Cytokines/P38MAPK/P53炎症相关通路的养阴润目丸治疗干眼的研究
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批准号:81674030
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项目类别:面上项目
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资助金额:55.0万元
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批准年份:2016
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负责人:李点
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依托单位:
基于“功能药对分析模式”研究逍遥散抗抑郁作用的BDNF/HPA/cytokines靶位整合调节机制
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批准号:81503277
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项目类别:青年科学基金项目
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资助金额:18.0万元
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批准年份:2015
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负责人:刘蓉
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依托单位: