Nuclear Spin Relaxation in Biomolecules as a Probe for Solution Dynamics and Structure

这个项目有两个组成部分。第一个涉及细胞色素b5与其他氧化还原伙伴蛋白之间1:1复合物的结构和功能特性，第二个涉及选定血红素蛋白的动态特性的NMR表征。研究将继续探索和阐明，使用不同的核磁共振方法，血红素蛋白的广泛动态特性，这可能是了解其生物物理特性和功能的关键。生物电子传递是目前研究最深入的生物过程之一，血红素蛋白在其中起着重要作用。了解这些重要分子的结构和动态运动，对于理解对生命至关重要的过程是必不可少的。

This project has two components. The first involves the structural and functional properties of the 1:1 complex between cytochrome b5 and other redox partner proteins and the second, the characterization by NMR of dynamic properties of selected heme proteins. The research will continue to explore and elucidate, using diverse NMR methods, a wide range of dynamic properties of heme proteins which are likely the key to understanding both their biophysical properties as well as their functions. Biological electron transport is currently one of the most intensely studied of biological processes in which heme proteins play a major role. Knowledge of the structures and dynamic motions of these important molecules is essential in understanding the processes so essential to life.