US-Sweden Cooperative Research: Ethnopharmacological Studies of Samoan Medicinal Plants

该奖项将支持杨百翰大学的Paul Cox博士和瑞典乌普萨拉大学的Lars Bohlin博士之间的合作研究。联合工作的主要目标是对萨摩亚的药用植物进行全面的药理筛选。波利尼西亚人在很大程度上开发了他们的岛屿植物，以发展本土的民族药物学系统。在这个联合项目中，由考克斯博士领导的美国团队将负责采访萨摩亚的治疗师，记录他们的植物知识，收集和鉴定他们使用的所有药用植物，并准备粗提物。由Bohlin领导的瑞典团队将使用体内和体外普通和特殊筛选来检查提取物的药理活性。显示_药理活性的粗提物将被分级，负责该活性的特定部分将被分离出来。瑞典团队还将为未来的结构确定准备摘录。这种国际和跨学科的合作应该为未来的民族药理学研究提供一个模式，并可能导致发现具有新的药理活性的新化合物。

This award will support collaborative research between Dr. Paul Cox, Brigham Young University and Dr. Lars Bohlin, University of Uppsala, Sweden. The principal objective of the joint work is to perform a comprehensive pharmacological screen of the medicinal plants of Samoa. The Polynesians have significantly exploited their island plants for the development of an indigenous system of ethnopharmacology. In this joint project, the U.S. team headed by Dr. Cox will be responsible for interviewing Samoan healers, recording their plant lore, collecting and identifying all medicinal plants used by them, and for the preparation of crude extracts. The Swedish team headed by Bohlin will examine the extracts for pharmacological activity using both in vivo and in __ ____ __ vitro general and specific screens. Crude extracts showing _____ pharmacological activity will be fractionated, and specific fractions responsible for the activity will be isolated. The Swedish team will also prepare extracts for future structural determination. This international and interdisciplinary collaboration should provide a model for future ethnopharmacological investigations and may potentially result in the discovery of new compounds with novel pharmacological activity.