Structure - Activity Relationships of Auxin and its Derivatives

在这个由萨格勒布Rudjer Boskovic研究所的Biserka Kojic-Prodic和布法罗医学基金会的William L. Duax合作的生物化学研究项目中，研究人员将研究植物生长激素生长素（或idole乙酸）在整个植物、细胞和分子水平上的调节作用。将合成或从天然来源分离出吲哚乙酸的化合物和衍生物；分析其结构和化学性质，并与植物的生物活性相关。南斯拉夫小组特别擅长合成和结构分析，而美国小组以其在结构-活性化学方面的工作而闻名。这项研究意义重大，预计将对生长素的受体、酶、结构及其与激素活性的关系产生新的信息。这个项目得到了美国-南斯拉夫科学和技术合作联合委员会的核可，并通过一个由美国和南斯拉夫政府相应捐款组成的联合基金得到支助。美国的捐款每年由国务院提供。没有涉及NSF基金。赠款提供给南斯拉夫的主要科学机构，但包括美国科学家前往南斯拉夫的旅费和南斯拉夫科学家在美国的生活费

In this U.S.-Yugoslav cooperative research project in biochemistry between Biserka Kojic-Prodic of the Rudjer Boskovic Institute in Zagreb and William L. Duax of the Medical Foundation of Buffalo, the investigators will study the regulatory action of a plant growth hormone, auxin (or idoleacetic acid), at the whole plant, cellular and molecular levels. Compounds and deriatives of idoleacetic acid will be synthesized or isolated from natural sources; analyzed for structural and chemical properties, and correlated with the plant's biological activity. The Yugoslav group is particularly expert at synthesis and structural analysis while the U.S. group is reknown for its work in structure-activity chemistry. The research is significant and is expected to yield new information about receptors, enzymes, and the structure of auxin and its relationship to hormonal activity, in particular. This project was approved by the U.S.-Yugoslav Joint Board on Cooperation in Science and Technology and is supported through a joint fund consisting of matching contributions from the governments of the United States and Yugoslavia. The U.S. contribution is provided annually by the Department of State. No NSF funds are involved. Grants are made to the principal scientific institution in Yugoslavia, but include dollar funds for U.S. scientist travel to Yugoslavia and for Yugoslav scientists' living expenses in the U.S.