CHEMICAL SCREENING AND OPTIMIZATION FACILITY - STRUCTURE ACTIVITY RELATIONSHIPS

化学筛选和优化设施 - 结构活性关系

• 批准号: 10022551
• 负责人: LEYI GONG
• 金额: $ 116.79万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10022551
• 关键词: Agonist; Biochemical; Biological Assay; Chemicals; Computer Simulation; Contraceptive Agents; Contraceptive methods; Contractor; Contracts; Development; Discipline; Female Contraceptive Agents; Fertility; Freedom; Generations; Goals; In Vitro; Lead; Male Contraceptive Agents; Methods; Mission; National Institute of Child Health and Human Development; Outcome; Pharmaceutical Chemistry; Pharmacology; Pregnancy; Process; Production; Proteins; Recombinant Proteins; Regulation; Research; Role; Series; Services; Structure-Activity Relationship; United States; Woman; X-Ray Crystallography; assay development; computational chemistry; drug development; drug discovery; high throughput screening; in vivo evaluation; men; novel; reproductive; screening; small molecule

Nearly half of all pregnancies in the United States are unintended. There is a critical need for fertility regulation methods that fit the needs of women and men throughout their reproductive lives. The objective of this contract is to support the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) in its mission to develop novel contraceptive methods by providing a Chemical Screening and Optimization Facility (CSOF) to identify safe and effective contraceptive agents for development. The CSOF also has an important role in the production of optimized compounds for early stage in vitro and in vivo testing.

在美国，几乎一半的怀孕是意想不到的。在生殖生活中，迫切需要适合男女需求的生育法规方法。该合同的目的是支持Eunice Kennedy Shriver国家儿童健康与人类发展研究所（NICHD），以通过提供化学筛选和优化设施（CSOF）来开发新型的避孕方法（CSOF），以识别开发的安全有效避孕药。 CSOF在生产优化化合物的早期体外和体内测试中也具有重要作用。