CHEMICAL SCREENING AND OPTIMIZATION FACILITY - "STRUCTURE ACTIVITY RELATIONSHIPS"

尤尼斯·肯尼迪·施莱弗国家研究院内的避孕研究分会 儿童健康和人类发展(NICHD)支持研究开发能够破坏人类健康的化合物 卵子发生、精子发生、正常排卵、精子成熟和/或提供 可为男性和/或女性实施的安全有效的避孕措施。《化学品》 筛选和优化设施(CSOF)旨在通过以下方式发挥独特的作用 确定、优化和进行小规模生产分子制剂，以实现 避孕效果。CSOF提供全面的项目管理和能力 根据开发新的避孕方法来支持这些目标：其中包括， 但不限于，重组多肽和蛋白质的产生，化验开发， 高通量筛选(HTS)、X射线结晶学、计算化学、医药 化学和药理学。CSOF确定和优化的化合物将在 用于进一步临床前评估的非良好制造规范(Non-GMP)。这个 CSOF在CRB的药物开发任务中发挥着关键作用。

The Contraception Research Branch (CRB) within the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) supports research to develop compounds that can disrupt oogenesis, spermatogenesis, normal ovulation, sperm maturation and/or function affording safe and effective contraceptives that can be implemented for men and/or women. The Chemical Screening and Optimization Facility (CSOF) is designed to fulfill a unique role by identifying, optimizing, and conducting small scale production of molecular agents that achieve a contraceptive effect. The CSOF provides overall project management and the capabilities to support these objectives pursuant to development of new contraceptive methods: these include, but are not limited to, the generation of recombinant peptides and proteins, assay development, high throughput screening (HTS), x-ray crystallography, computational chemistry, medicinal chemistry, and pharmacology. Compounds identified and optimized by the CSOF will be prepared under non-Good Manufacturing Practices (non-GMP) for further preclinical evaluation. The CSOF plays a critical role in the drug development mission of the CRB.