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The role of CYP26B1-mediated retinoic acid metabolism in regulating osteoblast differentiation in normal bone and heterotopic calcification of cardiovascular tissue

The role of CYP26B1-mediated retinoic acid metabolism in regulating osteoblast differentiation in normal bone and heterotopic calcification of cardiovascular tissue
CYP26B1介导的视黄酸代谢在调节正常骨成骨细胞分化和心血管组织异位钙化中的作用
批准号:
266647
负责人:
Petkovich Martin
金额:
$44.3万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2012
资助国家:
加拿大
项目状态:
已结题
起止时间:
2012-09-01 至 2017-09-01

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中文摘要
翻译
视黄酸(RA)是维生素A的活性形式,在胚胎发育和成年期的许多组织的形成和维持中起着重要作用。RA的活动需要通过机制来控制,以确保某些细胞的增殖。
英文摘要
Retinoic acid (RA), the active form of vitamin A, plays an essential role in the formation and maintenance of many tissues both during embryonic development and in the adult. The activity of RA needs to be controlled by mechanisms ensuring that certain ce
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Blocking RA Metabolism: A safer approach to retinoid therapy in skin disease
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