In depth characterisation of the gamma delta T cell immune synapse

本项目旨在全面揭示γ δ T细胞的激活原理。这些细胞在脊椎动物的免疫和发育中具有未充分研究但核心的作用。一个缺失的部分是γ δ T细胞如何感知压力以及这种信号如何导致激活。预期成果包括免疫学和结构生物学的基础知识的产生。该提案使用高技能技术，包括冷冻电子显微镜和单分子成像，并为研究生提供辅助好处。预期成果包括有影响力的出版物，在澳大利亚建立足够数量的专门知识，并促进与澳大利亚的国际合作。

This project aims to comprehensively characterise the activation principles of gamma delta T cells. These cells have an understudied but central role in vertebrate immunity and development. A missing piece of the puzzle is how gamma delta T cells sense stress and how this signal leads to activation. Expected outcomes include the generation of fundamental knowledge in immunology and structural biology. This proposal uses high-skilled techniques, including cryo-electron microscopy and single-molecule imaging and holds ancillary benefits to postgraduate students. Anticipated outcomes include influential publications, building a critical mass of expertise in Australia and fostering international collaborations with Australia at the epicentre.