Novel role of RNA methylation in neuronal homeostasis

这一建议旨在了解发生在神经元内稳态反应中的RNA信号。神经动态平衡对正常大脑功能的关键作用在整个神经系统中都得到了证实；然而，确切的潜在机制仍然没有被很好地理解。这项拟议的研究将利用高通量测序方法，结合生化、分子和细胞生物学分析，提供对控制神经元内稳态反应的分子过程的机械性见解。这将阐明神经可塑性和网络稳定性是如何维持的，这一过程对于我们理解感觉处理、学习和一生的记忆至关重要。

This proposal is aimed at understanding the RNA signalling that takes place in neuronal homeostatic response. The crucial role of neuronal homeostasis for normal brain function is evidenced throughout the nervous system; however, the precise underlying mechanisms are still not well understood. The proposed research will utilise high-throughput sequencing approaches coupled with biochemical, molecular and cell biological assays to provide mechanistic insights into the molecular processes that control neuronal homeostatic responses. This will elucidate how neural plasticity and network stability are maintained, a process that is critical for our understanding of sensory processing, learning and memory throughout life.