Phenotyping doublecortin+ cells to unravel human adult neurogenesis

这个项目研究了大脑中最显著的现象之一：成人神经发生，即在一个特殊的大脑区域（海马体）产生新的脑细胞，这种现象一直持续到成年。这一过程有助于许多物种的学习、记忆和再生能力。然而，这一过程是否发生在人类身上仍有很大争议。利用新的神经科学工具，该项目将通过深入检查表达新生细胞标记物双皮质素的海马细胞，对人类成人神经发生产生新的见解。这将有助于澄清人类成人神经发生的存在和程度，并为利用这一过程改善人类的学习、记忆和大脑再生提供基础。

This project investigates one of the brain’s most remarkable phenomena: adult neurogenesis, the birth of new brain cells in a specialised brain area (the hippocampus) occurring well into adulthood. This process contributes to many species’ capacity to learn, remember and regenerate. However whether this process occurs in humans is heavily debated. Using new neuroscience tools, this project will produce new insights into human adult neurogenesis by deeply examining hippocampal cells that express the newborn cell marker, doublecortin. This will enable clarification of the existence and extent of adult neurogenesis in humans, and provide the foundation to leverage this process for improving learning, memory and brain regeneration in people.