Presidential Young Investigator Award: Molecular Recognition and Biomimetic Chemistry

这个总统青年研究者奖在有机 和高分子化学计划提供支持， 伊利诺伊大学的史蒂文齐默尔曼博士的工作。这项工作 重点关注机械生物有机化学的两个领域： (1)DNA分子识别;（2）仿生 化学. DNA的分子识别将允许探针 选择性地与DNA结合。这些随后 将提供改变DNA特性的方法， 可以对其设计进行细微的改变。仿生 研究将有助于更好地了解各种 酶催化的各个方面。 更具体地说，分子“镊子”正在准备中 它们只与DNA末端结合 螺旋或结构异常，如建议的 β-扭结位点。此外，大沟嵌入剂是 正在调查仿生学研究已经产生了 立体电子校正电荷继电器模型 胰凝乳蛋白酶，目前正在详细研究。

This Presidential Young Investigator Award given in the Organic and Macromolecular Chemistry Program provides support for the work of Dr. Steven Zimmerman, University of Illinois. This work is focused on two areas of mechanistic bioorganic chemistry: (1) the molecular recognition of DNA and (2) biomimetic chemistry. Molecular recognition of DNA will allow probes to be developed which selectively bind to DNA. These subsequently will provide the means for changing the properties of DNA so subtle alterations in its design can be made. Biomimetic studies will allow a better understanding of the various aspects of enzymatic catalysis. More specifically, molecular "tweezers" are being prepared which are expected to bind exclusively at the end of DNA helices or at structural abnormalities such as the proposed beta-kink site. In addition, major groove intercalators are being investigated. Biomimetic studies have produced a stereoelectronically correct charge relay model for chymotrypsin which is currently being studied in detail.