Purchase of a Multinuclear 500 MHz NMR Spectrometer

核磁共振（NMR）光谱是化学家用来研究分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱学对于正在进行前沿研究的化学家和生物学家来说是必不可少的。南卡罗来纳大学哥伦比亚分校化学系将利用化学仪器项目和仪器与仪器开发项目的这笔资金，帮助获得一台高场核磁共振光谱仪。此次收购将加强的研究领域包括：1) 14族有机金属化合物的多核磁共振研究2)天然产物的合成3)细胞色素P-450-CAM与樟脑衍生物的相互作用4)胸腺嘧啶合酶二、三元配合物的构象动力学；5)过渡金属氢化物中质子自旋晶格弛豫时间作为区分经典与非经典结构的确定方法的研究；6)大环的合成。

Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectroscopy is essential to chemists and biologists who are carrying out frontier research. The Department of Chemistry at the University of South Carolina at Columbia will use this award from the Chemical Instrumentation Program and the Instrumentation and Instrument Development Program to help acquire a high-field NMR spectrometer. The areas of research that will be enhanced by the acquisition include: 1) Multinuclear magnetic resonance studies of Group 14 organometallic compounds 2) Synthesis of natural products 3) Interactions between cytochrome P-450-CAM and camphor derivatives 4) Conformational dynamics of selected binary and ternary complexes of thymidylate synthase 5) Studies of proton spin lattice relaxation times as a definitive method of distinguishing classical from nonclassical structures in transition-metal hydrides 6) Synthesis of macrocycles.