Substructure and Communication in Myosin and Actin

肌肉收缩需要肌球蛋白之间的周期性相互作用 头和肌动蛋白。 根据目前的观点， 涉及的几何形状或结构的一些变化， 肌动球蛋白复合物的力产生步骤期间， 收缩周期 该项目的目标是达到一个 肌球蛋白的结构和功能的详细描述 和肌动蛋白，它们之间的相互作用和调节 of this interaction互动. 大多数肌肉收缩模型表明， 肌细胞是通过肌球蛋白的周期性相互作用产生的 用肌动蛋白连接桥梁。 虽然分子的细节 虽然这一进程在很大程度上是未知的，但已经取得了令人印象深刻的进展， 最近在阐明肌球蛋白的结构方面， 肌动蛋白。

Muscle contraction requires a cyclic interaction between myosin heads and actin. According to current views this process involves some changes in the geometry or the structure of the actomyosin complex during the force generating step of the contractile cycle. The goal of this project is to arrive at a detailed description of the structures and functions of myosin and actin, their interaction with each other and the regulation of this interaction. Most models for muscle contraction show that the force in a muscle cell is generated through cyclic interaction of myosin crossbridges with actin. Although the molecular details of this process are largely unknown, impressive progress has been made in the recent past in elucidating the structures of myosin and actin.