Regulation of Tetrapyrrole Synthesis in Developing Chloroplasts

本研究将研究叶绿体ALA合成作为一种 异质现象，即两个ALA形成系统 必须存在，其中之一使ALA注定要 原叶绿素（Pchlide），而另一个填补了一个 池，不有助于Pchlide途径， 可能与血红素合成有关 本研究 将确定一个ALA池为Pchlide的前体， 另一个ALA池作为血红素的前体。 因此，我们认为， 将证明Mg和Mg之间的分支点 Fe四吡咯不位于原卟啉上， 一般认为，但在合成ALA本身。% 多年来，人们一直认为， 叶绿素合成的控制在于5- 氨基乙酰丙酸（ALA）。 ALA的合成是 在调节叶绿素以及吡咯的点 化合物. 本研究探讨了ALA的调节， 从生理学的角度，但使用生物化学的工具。 的 形成的各种代谢物之间的关系 在光合组织发育过程中， 确定。*//

This research will examine chloroplastic ALA synthesis as a heterogenous phenomenon, whereby, two ALA-forming systems must be present, one of which makes ALA that is destined to protochlorophyllide (Pchlide), while the other fills up a pool that does not contribute to the Pchlide pathway and that could possibly be involved in heme synthesis. This study will identify one ALA pool as the precursor of Pchlide and the other ALA pool as the precursor of protoheme. Therefore, it will be proven that the branching point between the Mg and the Fe tetrapyrroles is not located at protoporphyrin, as generally thought, but at the synthesis of ALA itself.%%% For a number of years it has been axiomatic that the coarse control of chlorophyll synthesis lies at the level of 5- aminolevulinic acid (ALA). ALA synthesis is the crucial point in the regulation of chlorophyll as well as the pyrrole compounds. This study approaches the regulation of ALA from a physiological perspective but using biochemical tools. The relationship between the various metabolites that are formed from ALA in developing photosynthetic tissue will be determined.***//