The Preparation and Study of Novel Chelating Systems

合成有机化学项目支持休斯顿大学化学系的Randolph P. Thummel博士的研究。Thummel博士正在开发一种分子合成技术，这种分子可以结合两个或两个以上的金属离子，然后将其定位，使它们能够相互作用。这种相互作用可能导致有趣的新特性，可用于农业，医学和工业所需的复杂材料。该研究概述了三种相关类型的螯合系统的设计和合成，每一种都能够结合多个金属中心。亚基如2,2'-联吡啶，8-羟基喹啉和ı3,2-g！吡啶多酚被间隔基团隔开，如四环十一烷（TCU）、1,8-二氮杂蒽、二茂铁等，它们使结合中心平行、平面或螺旋排列。这些体系将通过应用弗里德兰德缩合和费雪吲哚合成与适当的定向羰基体系制备。这些配体可以用Ru（II）、Pd（II）、Pt（II）和Eu（III）等金属来制备配合物。配体结构对所得金属配合物几何形状的影响将使用高场核磁共振和x射线分析进行评估。电化学和光化学性质将被检查，以帮助更好地了解配体和金属中心之间的相互作用。将探讨电荷转移中继、混合价态和主客体型相互作用的可能存在。预计能够取向两种或两种以上金属的配体将表现为有机模板，介导和促进不寻常的无机化学。

The Synthetic Organic Chemistry Program is supporting the research of Dr. Randolph P. Thummel of the Department of Chemistry at the University of Houston. Dr. Thummel is developing syntheses of molecules that will bind two or more metal ions which will be then positioned so that they can interact with one another. This interaction may lead to interesting new properties which can be used in the complex materials required by agriculture, medicine and industry. The research outlines the design and synthesis of three related types of chelating systems each of which is capable of binding more than one metal center. Sub-units such as 2,2'-bipyridine, 8-hydroxyquinoline, and ı3,2-g!pyridoindole are separated by spacer groups such tetracyclo-undecane (TCU), 1,8-diazaanthracene, ferrocene, and others which orient the binding centers in parallel, planar, or helical arrangements. These systems will be prepared by application of the Friedlander condensation and the Fisher Indole synthesis with appropriate oriented carbonyl systems. Complexes will be prepared with these ligands using metals such as Ru(II), Pd(II), Pt(II), and Eu(III). The impact of ligand structure on the geometry of the resulting metal complexes will be evaluated using high field NMR and X-ray analysis. Electrochemical and photochemical properties will be examined to help better understand interactions between the ligand and metal centers. The possible existence of charge transfer relays, mixed valence species, and host-guest typeinteractions will be explored. It is anticipated that ligands capable of orienting two or more metals will behave as organic templates which mediate and encourage unusual inorganic chemistry.