Transition-metal complexes in the Synthesis of Highly Unsaturated, Conjugated Molecules-Studies Towards the Total Synthesis of the Histrionicotoxins

少数民族机构研究改进（RIMI） 该项目将研究 高度不饱和和共轭分子的合成。 的 研究计划将更充分地探索钴的使用 用于保护乙炔和二炔单元的络合物。 这一阶段的结果将用于合成 histrionicotoxins一组复杂的有机分子 从这些实验中获得的知识将为以下方面提供理论基础： 更广泛的研究取代基和电子对 组胺毒素的药理学，这反过来会增加 我们对神经肌肉疾病的理解 这一雄心勃勃的研究络合反应， 过渡金属将大大增加研究 以少数族裔为主的机构的能力。 的 首席研究员具有出色的综合培训， 发表在权威期刊上。 教师和学生 从事这个项目的人将拥有化学方面的技能， 合成得到显著改善。

This Research Improvement in Minority Institutions (RIMI) project will study transition - metal complexes in the synthesis of highly unsaturated and conjugated molecules. The research plan will explore more fully the use of cobalt complexes for the protection of acetylene and diyne units. Results of this phase will be applied to the synthesis of histrionicotoxins, a set of complex organic molecules. Knowledge from these experiments will provide rationales for broader studies of substituent and electronic influences on the pharmacology of histrionicotoxins which in turn will increase our understanding of neuromuscular disorders. This ambitious examination of complexation reactions for transition metals will significantly increase the research capability of a predominantly minority institution. The principal investigator has excellent synthesis training and has published in refereed journals. Faculty and students working on this project will have their skills in chemical synthesis measurably improved.