Purchase of Superconducting FT-Nuclear Magnetic Resonance Spectrometer

通过核磁共振谱仪对耦合常数和化学位移数据的分析，可以了解探针核环境中细微变化所引起的分子间和分子内动力学。核磁共振数据有助于建立结构-功能相关性，其中中间体的结构阐明对于开发新的合成方案以制备生物活性化合物至关重要。这种分析的结果将对催化和药物设计与开发等领域产生影响。该奖项将允许位于北岭的加州州立大学化学系获得一台高场多核核磁共振波谱仪，用于以下化学领域的研究：汞桥接过渡金属簇的溶液动力学过渡金属簇的低温质子化3。三核簇中碳-金属氢交换速率立体定向合成生物活性磷脂氮氧化物自旋标签的核磁共振pinnacolamine及其相关化合物的构象分析海胆发育早期膜脂、酶及代谢的核磁共振研究

The analysis of coupling constants and the chemical shift data from a NMR spectrometer provides basic understanding of the inter- and intra- molecular dynamics associated with subtle changes in the environment of probe nuclei. The NMR data help establish structure-function correlations in which the structural elucidation of intermediates is critical for developing new synthetic schemes for the preparation of bioactive compounds. The results of such analysis would have impact in areas such as catalysis and drug design and development. This award will allow the Department of Chemistry at California State University at Northridge to acquire a high field multinuclear NMR spectrometer for research in the following areas of chemistry: 1. Solution Dynamics of Mercury Bridged Transition Metal Clusters 2. Low Temperature Protonations of Transition Metal Clusters 3. Rates of Carbon-Metal Hydrogen Exchange in Trinuclear Clusters 4. Stereospecific Synthesis of Biologically Active Phospholipids 5. NMR of Nitroxide Spin Labels 6. Conformational Analysis of Pinnacolamines and Related Compounds 7. NMR Studies of Membrane Lipids and Enzymes and the Metabolism in Early Sea Urchin Development