U.S.-West Europe Workshop on Genes and Development: Molecular and Logical Themes from Phage to Metazoa; Provence, France; May 7-11, 1990

该奖项支持五名年轻的美国生物学家参与 在一次国际会议上， 发育生物学研究中的实验遗传学。 的 会议是由几个欧洲和美国联合举办的 科学家们，包括威廉·F。威斯康星州大学的Dove和 法国巴黎巴斯德研究所的弗朗索瓦·雅各布。 会议 会议将于1990年5月7日至11日在法国普罗旺斯举行。 与会者 有一个共同的知识起点-理解 对遗传实验系统的理解和评价，即， 发现显著的发育突变体， 发展要素 然而，他们的工作与各种各样的 生物体，包括细菌、线虫、植物、果蝇、鸟类 和老鼠。 会议将审查成功和局限性 让30名左右的参与者熟悉 实验系统的使用，并鼓励新的思维模式 未来十年的发展生物学。 会议的具体主题包括控制转录 与翻译后的相互作用;谱系和两极分化; 细胞相互作用和信号传导;和遗传学的可分配 与基本发展过程的对比。 的框架 会议是综合性的问题，如：如何广泛地使用 调节环的形式化，以扩展我们对 发展？ 还原论传统在哪些方面起作用， 在哪些方面不是？ 什么有用的范式取代了第十九范式 世纪的预成/后生二元论？ 参与者包括 这一领域的几个主要贡献者以及一些有前途的 年轻的科学家将塑造发育生物学的未来。

This award supports the participation of five young U.S. biologists in an international conference addressing the relatively new role of experimental genetics in the study of developmental biology. The conference was jointly organized by several European and American scientists, including William F. Dove of University of Wisconsin and Francois Jacob of the Institut Pasteur, Paris, France. The meeting is to be held May 7 - 11, 1990, in Provence, France. The participants have a common intellectual starting point - an understanding of phages and an appreciation of genetical experimental systems, i.e., the discovery of salient developmental mutants to identify key developmenal elements. However, they work with a wide variety of organisms including bacteria, nematodes, plants, drosophila, birds and mice. The conference will review the successes and limitations of this approach, familiarize the 30 or so participants with the experimental systems being used, and encourage new modes of thinking about developmental biology for the coming decade. Specific themes of the meeting include control of transcription versus post-translational interactions; lineages and polar divisions; cell interaction and signalling; and the genetics of dispensible versus essential developmental processes. The framework of the meeting is integrative questions such as: How broadly can one use the formalisms of regulatory loops to extend our understanding of development? In what ways does the reductionist tradition work, and in what ways not? What useful paradigm replaces the nineteenth century dualism of preformation/epigenesis? Participants include several leading contributors to this field as well as some promising younger scientists who will shape the future of developmental biology.