Thermal Tomography using Electron Resonance (ESR) Techniques

基于氮氧化物稳定自由基电子自旋共振(ESR)光谱的层析成像技术将发展一种无创测量三维活体组织内的温度场的技术。这些研究将检查在实验和临床应用中可能遇到的温度变化，涉及哺乳动物体内的体温过高。实验包括三个主要部分：第一，将在模型系统中获得适当氮氧化物随温度变化的光谱的详细数据，如溶液和血液：第二，将在活的麻醉小鼠的组织中重新检查光谱，额外的目标是将信号定位到指定的位置，将信号定位到指定的小体积的附加小目标。第三，将对适用于该方法的层析成像技术的发展进行初步工作。这项研究最重要的成果将是非侵入性温度测量技术的突破。目前热疗程序的一个主要缺点是热疗应用区域内温度分布的不确定性。主要目的是开发一种有效且合理经济的体内使用技术。然而，该技术的变体也可以开发用于其他用途。因此，基于ESR的热层析成像将成为传热学技术和科学中一个重要的新组成部分。

A noninvasive technique for measuring the temperature field inside three-dimensional living tissue using tomographic methods based on electron spin resonance (ESR) spectroscopy of nitroxide stable free radicals will be developed. The studies will examine temperature variations likely to be encountered in experiments and in clinical applications involving hyperthermia in the mammalian body. The experiment consists of three major parts: First, detailed data on temperature dependent spectra of appropriate nitroxides will be obtained in model systems, such as solutions and blood: Second, the spectra will be reexamined in the tissues of living, anesthetized mice with the additional objective of localizing the signal to specified, small additional objective of localizing the signal to specified, small volumes. Third, preliminary work will be done on the development of tomographic applicable to this method. The most significant result of this research would be a breakthrough in noninvasive temperature measurement techniques. A major shortcoming of current hyperthermia procedures is the uncertainty of the temperature distribution in the region of the application of the thermal treatment. The primary aim is to develop an effective and reasonably economical technique for in vivo uses. Variations of the technique, however, could be developed for other uses as well. Thus, ESR based thermal tomography would become a significant new component in the art and science of heat transfer.