Synthesis of Cyclopeptide Alkaloids

Madeleine Joullie教授的这项研究计划 宾夕法尼亚大学化学系将 由有机合成计划支持。 校长 调查人员将继续调查 环肽生物碱的合成，并使用阐述 其他天然产物的合成方法。 环肽生物碱属于一个密切相关的组， 100多个大环聚酰胺植物基地 起源 这些化合物主要由简单的， 由酰胺键连接的天然氨基酸，除了一个 - 非氨基酸单元，其为苯乙烯胺部分，或 其衍生物。 除了一个例外，所有环肽 生物碱含有β-羟基氨基酸， 化合物的各种家族。 有证据表明 这些化合物起离子载体的作用， 从土壤中吸收养分，尤其是碱 金属离子 环肽的天然利用率低 生物碱使得合成路线的发展， 令人感兴趣的一类化合物。

This research program of Professor Madeleine Joullie in the Department of Chemistry at the University of Pennsylvania will be supported by the Organic Synthesis Program. The principal investigator will continue her investigations into the synthesis of cyclopeptide alkaloids, and to use the elaborated methodologies for the synthesis of other natural products. Cyclopeptide alkaloids belong to a closely related group of more than one hundred macrocyclic polyamide bases of plant origin. The compounds are primarily composed of simple, natural amino acids linked by amide bonds except for one non-amino acid unit which is a styrylamine portion or derivative thereof. With one exception, all cyclopeptide alkaloids contain a beta-hydroxyamino acid which distinguishes the various families of compounds. There is evidence that these compounds function as ionophores and may be involved in the absorption of nutrients from the soil, especially alkali metal ions. The low natural availability of the cyclopeptide alkaloids makes the development of synthetic routes to this interesting class of compounds desirable.