U.S.-Australia Cooperative Research: Control of Cytochrome P450 Gene Expression

该奖项将支持约翰L。新墨西哥州大学的Omdahl和阿德莱德大学（南澳）的Brian May博士。这项研究对于我们理解P450基因的多种多样的普遍存在的生物活性具有明显的意义。例如，一些P450基因在肝脏中表达以代谢外来化学物质，如药物，而其他基因在组织中表达以产生激素。具体而言，这些研究人员建议确定负责鸡中苯巴比妥代谢的P450基因的控制区域，并分离猪的P450基因，为将来确定这些基因对激素反应的控制区域奠定基础。该项目汇集了互补的专业知识，梅博士精通这些系统的分子生物学，奥姆达尔博士是他们的生物学专家。除了预期的科学进步及其在毒理学上的潜在应用外，阿德莱德大学的基因技术卓越中心还将作为一种资源，用于了解这些中心是如何组织和管理的，以在新墨西哥州大学获得潜在应用。

This award will support collaborative research between Dr. John L. Omdahl of the University of New Mexico and Dr. Brian May at the University of Adelaide (South Australia). The research is clearly significant in the development of our understanding of the ubiquitous biological activities of the many varieties of P450 genes. For example, some P450 genes are expressed in the liver to metabolize foreign chemicals such as drugs and others are expressed in tissues for hormone production. Specifically, these researchers propose to define the control region of the P450 gene responsible for metabolism of phenobarbital in chickens, and to isolate the P450 gene of the pig to lay the ground for future work in defining the control regions of these genes responsive to hormones. The project brings together complementary expertise in that Dr. May is well-versed in the molecular biology of these systems, and Dr. Omdahl is an expert in their biology. In addition to the scientific advances anticipated and their potential applications to toxicology, the University of Adelaide's Center of Excellence for Gene Technology will serve as a resource for understanding how such centers are organized and administered for potential application at the University of New Mexico.