Fluorescence Studies of Dynamic Processes in Peroxidase hemeprotein

该奖项支持生物物理学的合作研究 由芝加哥大学的大卫詹姆森指挥 夏威夷和天主教大学的胡安·布鲁内 智利瓦尔帕莱索。 这项工作将继续研究 在荧光光谱研究中， 血红素蛋白辣根过氧化物酶 它将 阐明蛋白质基质附近的动力学 血红素结合位点，特别是松弛过程。 将努力展示功能 蛋白质分子运动对酶的意义 催化和配体结合的能量学。 过氧化物酶催化各种有机物的氧化 和无机化合物，因此是一种有吸引力的 蛋白质动力学研究模型。 这项工作继续成功和富有成效的 Jameson博士的合作， 荧光光谱、仪器和理论 布吕内博士是一位训练有素的 物理化学家，他资助了一个新的 荧光计，部分是由于合作。 这和研究生所接受的培训 在智利接受说明的优势， 发展中国家科学计划。

This award supports cooperative research in biophysics to be conducted by David Jameson of the University of Hawaii and Juan Brunet of the Catholic University of Valparaiso, Chile. This work will continue research in fluorescent spectroscopic studies of the hemeprotein, horseradish peroxidase. It will elucidate the dynamics of the protein matrix near the heme binding site, particularly relaxation processes. An effort will be made to show the functional significance of protein molecular motions to enzyme catalysis and the energetics of ligand binding. Peroxidases catalyze the oxidation of various organic and inorganic compounds and are thus an attractive model for protein dynamic studies. This work continues a successful and productive collaboration between Dr. Jameson who is expert in fluorescence spectroscopy, instrumentation and theory of fluorescence and Dr. Brunet, a well-trained physical chemist who has funding for a new fluorometer, partly as a result of the collaboration. This and the training that graduate students are receiving in Chile illustrate the advantages of the Science in Developing Countries program.