Decoding Bacterial Epigenetic Regulation

该项目旨在通过确定细菌DNA甲基化的作用和影响的机制来表征细菌的表观遗传调控。该项目希望利用尖端DNA和RNA测序、蛋白质组学和生物信息学方法的新组合，产生关于细菌基因调控基本方面的新知识。这一项目的预期成果将提供新的工具，促进表观基因组分析与基因组研究的结合，成倍增加收集的数据量和价值。这将为所有涉及细菌基因组分析的学术、生物技术、农业、兽医和制药应用提供重大的未来好处。

This project aims to characterise bacterial epigenetic regulation by determining the mechanism of action and impact of bacterial DNA methylation. This project expects to generate new knowledge about fundamental aspects of bacterial gene regulation, using a novel combination of cutting edge DNA and RNA sequencing, proteomic and bioinformatic approaches. The expected outcomes of this project will provide new tools to facilitate the integration of epigenomic analysis into genomic studies, exponentially increasing the volume and value of data gathered. This would provide significant future benefits to all academic, biotechnology, agricultural, veterinary and pharmaceutical applications that involve bacterial genomic analysis.