Engineering Plants for Resistance Against Pathogens

加州大学戴维斯分校将建立一个科学和 抗虫植物工程技术中心 病原体 该中心的主任将是乔治教授。 勃鲁宁 该中心的目标是开发一个综合的分子和 了解植物对不同病原体的反应。 番茄将被开发为这些研究的模式生物。 与会者将包括来自大学的教师， 加州，戴维斯和伯克利分校，康奈尔大学， 华盛顿大学的科学家和Calgene公司的科学家。 该中心有三个主要研究目标： 1. 介导病原体识别的基因和分子， 植物将被描述。 参与的分子类型 植物-寄生虫相互作用的早期决定性阶段将 识别并用于展示识别能力 植物的防御机制 2. 敏感和抗性宿主的分子特征 将通过识别基因和 这些分子在易感和 抵抗反应。 信号转导途径和调控 机制将从遗传学和生物化学角度进行剖析。 基因 可能介导易感或耐药反应的基因 在转基因植物中进行功能分析。 3. 干扰病原体增加的新策略， 运动或传输将被开发。 最初的重点 将是关于病毒复制和传播的机制。 卫星和缺陷干扰RNA的功效， 表达病毒外壳蛋白的转基因植物，以及 表达有缺陷的传递蛋白的植物， 研究了 宿主-病原体相互作用的分子基础是 植物生物学中的重大未知数 成功完成 这部作品的基本方面应该导致小说的发展 是指控制各种作物的植物病害。 这将 从而减少化学杀真菌剂和杀虫剂的用量 作物保护所需的，从而减少了产量， 成本和环境污染。 该中心将促进加强跨学科培训， 植物科学和人力资源开发。

The University of California, Davis, will establish a Science and Technology Center for Engineering Plants for Resistance Against Pathogens. The Director of the Center will be Professor George E. Bruening. The goal of the center is to develop an integrated molecular and biochemical understanding of plant responses to diverse pathogens. The tomato will be developed as a model organism for these studies. Participants will include faculty from the University of California, Davis and Berkeley campuses, Cornell University, Washington University, and scientists from Calgene, Inc. The Center has three major research objectives: 1. Genes and molecules that mediate recognition of pathogens by plants will be characterized. The types of molecules involved in the early determinative phases of plant-parasite interactions will be identified and used to demonstrate the recognition capabilities of the plants' defense mechanisms. 2. Molecular characterization of susceptible and resistant host responses will be accomplished by identifying the genes and molecules that are differentially regulated during susceptible and resistant responses. Signal-transduction pathways and regulatory mechanisms will be dissected genetically and biochemically. Genes that potentially mediate susceptible or resistant responses will be functionally analyzed in transgenic plants. 3. Novel strategies for interfering with pathogen increase, movement, or transmission will be developed. The initial focus will be on the mechanisms of viral replication and transmission. The efficacy of satellite and defective interfering RNAs, transgenic plants expressing viral coat protein, and transgenic plants expressing defective transmission proteins will be investigated. The molecular basis of host-pathogen interactions is one of the major unknowns in plant biology. Successful completion of the basic aspects of this work should lead to the development of novel means to control plant disease in a variety of crops. This would in turn reduce the amount of chemical fungicides and pesticides required for crop protection, thereby reducing both production costs and environmental contamination. The center will stimulate enhanced interdisciplinary training in the plant sciences and the development of human resources.