Protein Crystal Growth Technology

该奖项为改进用于制备单个蛋白质晶体的技术提供了资金，用于随后的x射线衍射分析。该奖项将允许该领域的一位领导者对几种明确且广泛可用的蛋白质的晶体生长进行系统的研究。这些研究的数据有望为其他希望规范和完善自己的技术的研究者提供很好的参考。近年来，x射线晶体学在酶和其他蛋白质的结构和功能分析中起着核心作用。这一领域的大部分进展是由于衍射数据的收集和分析的进展；尽管在了解蛋白质晶体生长过程方面已经取得了一些进展，但在大多数蛋白质的分析中，难以生长出足够大小和质量的晶体仍然是一个重要的绊脚石。获奖者将要进行的各种研究应该有助于使这方面的结构研究更加常规，从而促进许多新蛋白质的分析。

This award provides funds for the improvement of techniques used in the preparation of crystals of single proteins for subsequent analysis by X-ray diffraction. The award will permit systematic studies of the growth of crystals of several well defined and widely available proteins by one of the leaders in this field. The data from these studies are expected to serve as an excellent reference for other investigators who wish to standardize and perfect their own technique. In recent years, X-ray crystallography has assumed a central role in the structural and functional analysis of enzymes and other proteins. Much of the progress in this area has been due to progress in the collection and analysis of the diffraction data; although there has been some progress in understanding the process of protein crystal growth, difficulty in growing crystals of sufficient size and quality remains a significant stumbling block in the analysis of most proteins. The kinds of studies to be undertaken by the awardee should help to make this aspect of structural studies more routine and thus to facilitate the analysis of many new proteins.