Purchase of a Nuclear Magnetic Resonance Spectrometer

要详细研究更复杂结构中的分子内和分子间相互作用--DNA、多肽和小蛋白质、复杂的天然产物、多金属物种和酶模拟物--需要较少的常规1D核磁共振实验、各种2D核磁共振实验的脉冲序列、溶剂抑制和变温实验。多核高场NMR非常适合用于这些更复杂的结构。这些核磁共振研究的结果在聚合物、催化和生物学等领域都是有用的。这项来自化学共享仪器计划的奖项将帮助伊利诺伊大学化学系获得400 MHz核磁共振波谱仪。400 MHz核磁共振波谱仪将用于以下化学领域的研究：1.类异戊二烯生物合成的特异性和新的方法学用于有机合成2.过渡金属介导的有机反应的合成和机理研究3.可溶性氧化物的选择氧化化学4.酶-辅酶结合部位的空间探针--2D核磁共振技术5.噻吩络合物的新配位模式6.六价金属有机配合物的选择氧化.血红素蛋白的合成类似物8.需要氟核磁共振能力9.抗生素和海洋衍生化合物的结构和生物合成10.有机合成和机理研究化学11.三链Diels-Alder反应的进一步研究12.合成结构和力学有机化学

A detailed study of intra- and intermolecular interactions in more complicated structures -- DNA, polypetides and small proteins, complex natureal products, polymetallic species and enzyme mimics requires less routine 1D NMR experiments, pulse sequences for various 2D NMR experiemtns, solvent supression, and variable temperature experiments. Multinuclear high field NMRs are ideally suited for use in these more complicated structures. The results from these NMR studies are useful in areas, such as polymers, catalysis, and in biology. This award from the Chemistry Shared Instrumentation Program will help the Department of Chemsitry at the University of Illinois acquire 400 MHz NMR spectrometer. The 400 MHz NMR spectrometer will be used in research investigations in the following areas of chemistry: 1. Specificity of Isoprenoid Biosynthesis and New Methodology for Organic Synthesis 2. Synthetic and Mechanistic Studies of Transition Metal- Mediated Organic Reactions 3. Selective Oxidation Chemistry on Soluble Oxides 4. Dimensional Probes of Enzyme-Coenzyme Binding Sites - 2D NMR Techniques 5. New Coordination Modes for Thiophene Complexation 6. Selective Oxidation with Osmium (VI) and Ruthenium (VI) Organometallic Complexes 7. Synthetic Analogues of Heme Proteins 8. Need for Fluorine NMR Capability 9. Structures and Biosynthesis of Antibiotics and Marine- Dervied Compounds 10. Synthetic and Mechanistic Investigations in Organic Chemistry 11. Further Studies of the Triplex Diels-Alder Reaction 12. Synthetic Structural and Mechanistic Organic Chemistry