Reactions and Stereochemistry of Organometallic Compounds Related to Asymmetric Synthesis and Catalytic Activity

无机化学、生物无机化学和金属有机化学项目的目标是开发以钨和钼等过渡金属化合物为基础的有机化合物的立体选择性合成的新方法。这种方法非常重要，因为分子的三维结构可以深刻地影响其化学和生物特性。该项目的两个目标是开发利用金属络合物进行不对称和区域选择性合成的新方法，以及阐明立体选择性反应的机理，这些反应在合成上是有用的。还将探讨氧化态较高的有机金属络合物在这些应用中的潜在用途。将开发一种新的方法来获取有机金属化合物在溶液中的详细结构信息。将设计和合成与有机金属结合的含有顺磁性金属离子的配体。使用这些新的位移试剂的核磁共振测量将允许详细描述反应性金属有机物种的结构(角度和距离)，特别是催化中间体，它们只存在于溶液中。

The goal of this project in the Inorganic, Bioinorganic and Organometallic Chemistry Program is the development of new methods for stereoselective synthesis of organic compounds based on compounds containing such transition metals as tungsten and molybdenum. Such methods are extremely important because the three-dimensional structure of a molecule can affect profoundly its chemical and biological properties. The two aims of the project are the development of new methods using metal complexes for asymmetric and regioselective syntheses and the elucidation of the mechanisms of stereoselective reactions which are synthetically useful. The potential utility of higher oxidation state organometallic complexes for these applications will be explored also. A new method will be developed for obtaining detailed structural information for organometallic compounds in solution. Ligands containing paramagnetic metal ions which bind to organometallics will be designed and synthesized. NMR measurements using these new shift reagents will allow detailed delineation of structure (angles and distances) of reactive organometallic species, especially catalytic intermediates, which exist only in solution.