Molecular Mechanisms of Sodium Channel Sorting in Neurons

神经细胞的活动依赖于各种离子穿过细胞 膜通过通道，有时是非常具体的。 这些通道由膜中的蛋白质分子形成。 神经细胞通常有一个很长的突起， 来自于被称为索马的细胞体。 轴突中的通道 与索马中的分布不同。 这 研究解决了不同的蛋白质， 在神经细胞的索马中不断合成， 空间分布。 该项目将研究分子 分类神经细胞中钠通道蛋白的机制。 钠通道蛋白质在索马中合成，但在细胞质中合成。 在轴突的膜中发现，而在索马中不存在。在 乌贼，一种无脊椎动物，从大鼠钠通道编码的mRNA 将被注入索马。 因此，细胞将 合成两种不同类型的钠离子通道 可以比较两种蛋白质的空间分布 分子。 分子的一部分负责其独特的 可以通过改变编码来改变空间分布， 因此能够被识别。 这项研究将促进我们的 了解神经细胞如何长期调节 功能

Nerve cell activity depends on various ions crossing the cell membrane through channels that are sometimes very specific. These channels are formed by protein molecules in the membrane. Nerve cells often have a long process, the axon which extends from the cell body known as the soma. Often channels in the axon are distributed differently from those in the soma. This research addresses the question of how different proteins, which are continuously synthesized in the soma of nerve cells, are spatially distributed. This project will examine the molecular mechanisms of sorting sodium channel proteins in nerve cells. Sodium channel proteins are synthesized in the soma, but are found in the membrane of the axon and are absent in the soma. In the squid, an invertebrate, mRNA coding from rat sodium channels will be injected into the soma. As a result the cells will synthesize two different types of sodium channels making it possible to compare the spatial distribution of the two protein molecules. The part of the molecule responsible for its peculiar spatial distribution can be changed by changing the coding and thus is able to be identified. This study will advance our understanding of long-term regulation of how nerve cells function.