Neuromuscular and Central Control Elements in Animal Escape Response

动物逃避反应中的神经肌肉和中枢控制元件

• 批准号: 9631511
• 负责人: William Gilly
• 金额: $ 21.49万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-15 至 2000-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9631511&HistoricalAwards=false
• 关键词: Neuromuscular; Central; Control; Elements; Animal

9631511 Gilly Research on the giant axon system of the squid during the past 50 years has provided the foundation for our understanding of communication within and between neurons - nerve impulse conduction and synaptic transmission. The basic mechanisms governing these processes are shared by all organisms with nervous systems, from jellyfish to humans. Much remains to be learned about the dynamic interactions that occur between individual nerve and muscle cells and how these interactions change during the acquisition of new behaviors. Background work indicates that giant and non- giant motor systems in squid can act independently to achieve a large range of jet velocities or, in close concert, to achieve super-charged jetting. Experiments funded by this grant are designed to examine the interactions between these two motor systems during escape behavior and to describe changes in these interactions that occur shortly after hatching. Preliminary work has shown that these developmental changes are strongly linked to the experience-dependent acquisition of prey capture behavior. It is expected that this work will provide new insights into how activity of specific motor nerve cells is coordinated by the brain to produce complex behavioral outputs and how development of this motor coordination is influenced by experiences early in life.

小行星9631511 在过去的50年里，对鱿鱼巨大轴突系统的研究为我们理解神经元内部和之间的通信-神经冲动传导和突触传递-提供了基础。 从水母到人类，所有具有神经系统的生物体都有控制这些过程的基本机制。 关于个体神经和肌肉细胞之间发生的动态相互作用，以及这些相互作用在获得新行为过程中如何变化，还有很多东西有待了解。 背景工作表明，鱿鱼中的巨型和非巨型马达系统可以独立地起作用以实现大范围的喷射速度，或者紧密地协同作用以实现增压喷射。 由该基金资助的实验旨在研究这两个运动系统之间的相互作用，在逃避行为，并描述这些相互作用的变化，孵化后不久发生。 初步研究表明，这些发育变化与依赖经验的猎物捕获行为的获得密切相关。 预计这项工作将为大脑如何协调特定运动神经细胞的活动以产生复杂的行为输出以及这种运动协调的发展如何受到生命早期经历的影响提供新的见解。