Biomimetic Oxidation Chemistry

在这个由有机动力学项目资助的项目中， 哥伦比亚大学化学系的Cynthia J. Burrows教授 位于斯托尼布鲁克的纽约州立大学将研究 “Biomimetic Oxidation Chemistry”. 生物学机制 碳氢化合物的氧化和卤化将提供基础 用于设计新的过渡金属催化剂， 流程. 使用金属氧化有机基质 催化剂对于石化工业是非常重要的， 特别是因为含氧化合物（主要是醚） 将对汽油工业产生重大影响。 机制研究正在进行中，以确定 镍和配体在催化环氧化反应中的作用 烯烃与末端氧化剂。 新的大环配体将 允许研究反应中的不对称诱导 与烯烃。 这些实验将试图区分 金属氧物种与电子之间的中间性 转移机制。 将应用机械信息 设计新的基于自由基的氧化转化 环化或开环反应。 相关组转移 例如氮丙啶化和环丙烷化的反应将被 研究，以及其他金属配合物。

In this project funded by the Organic Dynamics Program, Professor Cynthia J. Burrows of the Chemistry Department at State University of New York at Stony Brook will study "Biomimetic Oxidation Chemistry". Biological mechanisms of hydrocarbon oxidation and halogenation will provide the basis for the design of new transition metal catalysts for these processes. The oxidation of organic substrates using metal catalysts is of great importance to the petrochemical industry, especially since oxygen-containing compounds (primarily ethers) will have great impact on the gasoline industry. Mechanistic studies are underway in order to characterize the roles of nickel and the ligand in the catalytic epoxidation of alkenes with a terminal oxidant. New macrocyclic ligands will allow the investigation of asymmetric induction in reactions with alkenes. These experiments will seek to distinguish between the intermediacy of metal oxo species versus electron transfer mechanisms. Mechanistic information will be applied to the design of new oxidative transformations based on radical cyclization or ring opening reactions. Related group transfer reactions such as aziridination and cyclopropanation will be investigated, as well as other metal complexes.