Long & Medium Term Research: The Mammalian Y Chromosome, Sex Determination and Evolution, A Marsupial Approach

长期中期研究：哺乳动物Y染色体，性别 决定和进化，有袋类动物的方法 该奖项是根据长期计划提出的。 &在国外卓越中心的中期研究。 的 该计划旨在使美国科学家和工程师能够 在国外的研究机构进行长期研究， 证明卓越。 奖项提供了机会， 开展联合研究，以及使用独特或复杂的 实验设施、专业知识和实验条件 国外 这个奖项是由琳达博士赞助的。Strausbaugh 将支持博士为期12个月的博士后研究访问。 格雷戈里·K康涅狄格大学的Hampikian工作 Jennifer M博士拉筹伯大学的坟墓，本多拉， 维多利亚，澳大利亚，关于“哺乳动物Y染色体进化 性别决定：有袋类动物的方法。“占主导地位的 哺乳动物Y染色体进化理论预测， 只有Y基因是参与性别决定的基因， 男性特有的特征和X-Y配对。 有袋类（下类 后兽亚目）从胎盘动物（下纲 Eutheria）至少1.3亿年前。 研究人员 建议分离出在亚类之间保守的基因， 从有袋类Y染色体的特定文库中提取， 哺乳动物性别决定的一般计划， 性染色体的进化 有袋类动物Y是理想的 对于这些比较研究，因为其尺寸小（2-3 X 1，000，000个基地），促进图书馆建设及其 缺少X染色体配对区域简化了特征， zation. 授标建议提供资金， 适当的，国际旅行，出国当地旅行， 津贴，家属津贴（如适用）和公寓 美国本土机构的行政津贴为250美元。

Long & Medium-Term Research: The Mammalian Y Chromosome, Sex Determination and Evolution, A Marsupial Approach This award recommendation is made under the Program for Long & Medium-Term Research at Foreign Centers of Excellence. The program seeks to enable U.S. scientists and engineers to conduct long-term research abroad at research institutions of proven excellence. Awards provide opportunities for the conduct of joint research, and the use of unique or comple- mentary facilities, expertise and experimental conditions in foreign countries. This award for a proposal sponsored by Dr. Linda A. Strausbaugh will support a 12-month postdoctoral research visit by Dr. Gregory K. Hampikian of the University of Connecticut to work with Dr. Jennifer M. Graves of La Trobe University, Bundoora, Victoria, AusPtralia, on "Mammalian Y-Chromosome Evolution and Sex Determination: A Marsupial Approach." The predominant theory of mammalian Y chromosome evolution predicts that the only Y genes conserved are those involved in sex determination, male-specific traits, and X-Y pairing. Marsupials (infraclass Metatheria) diverged from placental animals (infra class Eutheria) at least 130 million years ago. The researchers propose to isolate genes conserved between the infraclasses from a marsupial Y-specific library in order to detail the general plan of mammalian sex determination and shed light on the evolution of sex chromosomes. The marsupial Y is ideal for these comparative studies because its small size (2-3 X 1,000,000 bases) facilitates library construction and its lack of an X chromosome pairing region simplifies characteri- zation. The award recommendation provides funds to cover, as appropriate, international travel, local travel abroad, stipend, dependents' allowance if applicable, and a flat administrative allowance of $250 for the U.S. home institution.