A Role for Serotonin in the Control of Sympathetic Nerve Activity

本研究旨在研究脑干脊髓和髓质的特定神经通路在交感神经系统控制中的作用。该方案的独特之处在于PI可以通过两种化学标识符来识别特定的神经通路。有些途径含有血清素，有些途径含有促甲状腺激素释放激素（TRH），但只有一种途径同时含有这两种物质，只有通过结合使用这些递质，才能识别和定义该途径。这项研究将大大增加我们对大脑控制交感神经系统的理解的准确性。

This proposal is to study the role of a specific neural pathway in the spinal cord and medulla of the brainstem in the control of the sympathetic nervous system. The uniqueness of this proposal is that the PI can identify a specific neural pathway by two chemical identifiers. Some pathways contain serotonin and some contain thyrotropin releasing hormone (TRH) but only one pathway contains both and it is by the combined use of these transmitters that the pathway can be recognized and defined. The study should add greatly to the accuracy of our understanding of brain control of the sympathetic nervous system.