Synthesis of Vitamin K Models

有机动力学计划将支持保罗·多德教授的 化学中“维生素K模型化合物的合成”研究 在匹兹堡大学的部门。 维生素K是 凝血所需的，在那里它是一个重要的辅因子 在称为血液凝固的复杂酶序列中 级联。 本研究将探索一种新的实验模型， 维生素K依赖性羧化反应，因为在 羧化作用的缺乏抑制了血液凝固。 各种各样的方法被用来研究新的 维生素K依赖性羧化的实验模型 反应，包括分子间和分子内缩合 反应，氧标记实验，探索新的 强碱和新的氧化反应。 模型实验 将决定分子氧是否会触发 羧化反应，通过与阴离子形式的 维生素K对苯二酚产生维生素K氧化物， 形成提供了必要的能量， 足够强以实现羧化。

The Organic Dynamics program will support Professor Paul Dowd's study of "Synthesis of Vitamin K Models" in the Chemistry Department at the University of Pittsburgh. Vitamin K is required for blood clotting, where it is an essential cofactor in the complex enzymic sequence known as the blood clotting cascade. This study will explore a new experimental model for the vitamin K-dependent carboxylation reaction since in the absence of carboxylation blood clotting is inhibited. A variety of methods are being used to study the new experimental model for the vitamin K-dependent carboxylation reaction, including inter- and intramolecular condensation reactions, oxygen labelling experiments, exploration of new strong bases, and new oxygenation reactions. Model experiments will determine whether molecular oxygen triggers the carboxylation reaction by reacting with the anionic form of vitamin K hydroquinone to produce vitamin K oxide, whose formation provides the energy necessary to furnish a base sufficiently strong to effect carboxylation.