Synthetic Applications of Photocycloadditions

有了这个奖项，合成有机项目将支持北卡罗来纳大学教堂山分校化学系迈克尔·t·克里明斯博士的研究。克里明斯博士将开发利用光环加成反应形成四元环的方法。然后，这些含环化合物将被修饰成有用的合成中间体。该项目将开发光化学的效用，分子内ı2+2！环加成-环丁烷断裂序列。主要的重点将放在使用分子内光环添加物来快速增加分子复杂性，同时保持高度的立体化学控制。几种天然产物的合成将用于表明该方法的多功能性。

With this award, the Synthetic Organic Program will support the research of Dr. Michael T. Crimmins of the Department of Chemistry at the University of North Carolina at Chapel Hill. Dr. Crimmins will develop methodology that uses photocycloaddition reactions to form four-membered rings. These ring containing compounds will then be modified into useful synthetic intermediates. The project will develop the utility of photochemical, intramolecular ı2+2! cycloaddition-cyclobutane fragmentation sequences. The primary emphasis will be placed on the use of intramolecular photocycloadditions to rapidly increase molecular complexity while maintaining a high degree of stereochemical control. The synthesis of several natural products will be used to indicate the versatility of the approach.