Molecular Genetic Variation in Pacific Populations

长期以来，人类学家一直对人类历史感兴趣。 人口。 南太平洋人口一直是一个问题地区， 在人们的迁徙问题上达成共识 迁移的时间， 种群之间，进化变化的速度和 如. 随着重组DNA技术的出现， 为解决这些长期存在的问题寻找新方法的潜力。 斯通金建议将DNA的各种成分从 数百人代表四个广泛的领域-新 几内亚、澳大利亚、印度尼西亚和萨摩亚。 DNA序列数据 并且与寡核苷酸探针杂交将允许 在基因水平上比较这些群体。 使用 利用统计和计算机技术， 澄清群体之间的关系，从而帮助 解决南太平洋的人口问题。 将分析线粒体（mtDNA）和核DNA。 一 特别有趣的方面将是斯通金的分析 Y染色体上的可变序列。 线粒体DNA是 通过母系遗传，而Y染色体是 通过父系传递。 尽管存在很多争论 关于mtDNA进化的解释，这些数据将 特别是有趣的调查。

Anthropologists have long been interested by the history of human populations. South Pacific populations have been a problem area in terms of developing a consensus about the migrations of people into the area - the timing of migrations, the relationships between populations, the rates of evolutionary change and the like. With the advent of recombinant DNA technology, there are potentials for new approaches to these long-standing problems. Stoneking proposes to isolate various components of the DNA from several hundred humans representing four broad areas - New Guinea, Australia, Indonesia and Samoa. Data on DNA sequences and hybridization with oligonucleotide probes will allow the comparisons of these groups at the genetic level. With the use of statistical and computer techniques, it will be possible to clarify the relationships between the groups and thus help to resolve the peopling of the South Pacific. Both mitochondrial (mtDNA) and nuclear DNA will be analyzed. A particularly interesting aspect will be Stoneking's analysis of variable sequences on the Y chromosome. Mitochondrial DNA is inherited through the maternal line while Y chromosomes are passed through the paternal line. As much debate exists regarding interpretations of mtDNA evolution, this data will allow especially interesting investigations.