A Biologically Responsive and Anatomically Authentic Human Nasal Model

随着污染物和病毒引起的呼吸道疾病越来越普遍，研究感染/保护机制和鼻腔给药/疫苗的人类鼻腔模型变得越来越重要。本项目旨在开发世界上第一个人类鼻腔模型，以模拟鼻腔的解剖学和生物学方面，并预测鼻黏膜细颗粒的分布和沉积以及由此产生的生物反应。其目的是克服一个关键的制造挑战- 3D打印一个解剖学上准确的鼻腔结构，具有多孔壁，在其上生长和成熟的功能性鼻组织排列在鼻腔壁上。这样做的好处是能够更快地开发出更有针对性的药物和疫苗。

As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.